Description

✅ Uses

• Gastroesophageal Reflux Disease (GERD) and acid reflux: Helps relieve heartburn, acid regurgitation, chest discomfort, and heal esophageal lesions by reducing stomach acid and improving motility Apollo Pharmacy+15TrueMeds+151mg+15.

• Peptic ulcers (gastric/duodenal): Promotes healing by decreasing gastric acidity and aiding ulcer recovery 1mgGetOMeds.

• Also used for general stomach upset related to acid or delayed gastric emptying, including nausea and bloating 1mgGetOMeds.

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🧬 How It Works

• Rabeprazole is a proton pump inhibitor (PPI) that blocks stomach acid production, allowing ulcer/erosion healing Drug Carts+12TrueMeds+121mg+12.

• Domperidone is a prokinetic that speeds up gastric emptying and strengthens lower esophageal sphincter tone — reducing reflux and nausea MIMS+5Steris Online+51mg+5.

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⚠️ Common Side Effects

These generally mild, often temporary effects may occur blog.jaynish.me+7TrueMeds+71mg+7:

• Headache, dizziness, drowsiness

• Dry mouth, diarrhea, constipation, stomach/abdominal pain, flatulence

• Nausea, vomiting, weakness

• Occasionally nasal congestion, insomnia, pharyngitis (sore throat) MedicinesFAQ+81mg+81mg+8

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📌 Specific or Less Common Side Effects

• Hyperprolactinemia, leading to galactorrhea (milk discharge), breast tenderness/enlargement, menstrual irregularities, decreased libido (domperidone-related) MIMS+8MedicinesFAQ+8GetOMeds+8.

• Rare cardiac arrhythmias (domperidone can affect heart rhythm) 1mg1mg.

• Rare skin rash, itching, nervousness MedicinesFAQ.

• Long‑term PPI use (rabeprazole) may lead to nutrient deficiencies (e.g. magnesium, calcium) and bone density loss 1mg+71mg+71mg+7.

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👩‍⚕️ Precautions & Warnings

• Driving/Machinery: May cause dizziness/drowsiness, avoid if affected TrueMeds1mg.

• Pregnancy/Breastfeeding: Not recommended without medical advice due to limited safety data and risk of increased prolactin PlatinumRx+9MedicinesFAQ+9TrueMeds+9.

• Liver/Kidney impairment: Caution and dose adjustment advised TrueMeds+11mg+1.

• Children & elderly: Children risk extra-pyramidal symptoms; elderly may experience increased side effects MedicinesFAQ.

• Allergies: Avoid if hypersensitive to domperidone or rabeprazole 1mg+4TrueMeds+4GetOMeds+4.

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🔗 Drug Interactions

• Cardiac glycosides (e.g. digoxin) – absorption altered by domperidone TrueMeds.

• Anticoagulants (e.g. warfarin) – PPI can affect bleeding risk 1mg+2TrueMeds+21mg+2.

• Macrolide antibiotics, antifungals, antivirals – can affect rabeprazole levels TrueMeds1mg.

• Opioids/anti-muscarinics – may blunt domperidone’s effects on motility MedicinesFAQ.

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💊 Dosage & Administration

• Adults: Usually one capsule (30 mg domperidone/20 mg rabeprazole), taken 30–60 minutes before a meal, often before breakfast MedicinesFAQ+3TrueMeds+31mg+3.

• Children: Dosed by body weight (0.2–0.4 mg/kg domperidone component), only under strict medical supervision MedicinesFAQ.

• Duration: Typically up to 12 weeks for reflux; follow your doctor’s guidance MedicinesFAQ1mg.

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🏥 When to Contact a Doctor

Seek medical advice if you experience:

• Chest pain, severe dizziness, irregular heartbeat

• Persistent diarrhea, vomiting, fever or severe stomach pain

• Signs of prolactin increase (galactorrhea, breast changes, libido drop)

• Any severe allergic reactions or neurological issues

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📝 Summary Table