Description

🩺 What It’s For

• Primary use: Management of osteoarthritis—particularly in knees and hips. It helps reduce joint pain, inflammation, and stiffness while supporting cartilage repair over time (PharmEasy, 1mg).
• The ingredients and dose per tablet typically include:
  • Diacerein 50 mg – an anti-inflammatory that slows cartilage degradation (MedPlusMart).
  • Glucosamine Sulfate 446–750 mg – supports cartilage structure and function (1mg).
  • MSM 250 mg – offers sulfur for joint tissue repair and has antioxidant/anti-inflammatory effects (MedPlusMart).

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✅ How It Works

• Diacerein inhibits inflammatory cytokines (like IL‑1β), reducing cartilage breakdown (TrueMeds).
• Glucosamine promotes synthesis of cartilage components, improving joint lubrication (WebMD).
• MSM supplies sulfur aid tissue repair and complements anti-inflammatory benefits (1mg).
• Time to relief: Often takes several weeks of consistent use to experience noticeable effects (PlatinumRx).

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⚠️ Common Side Effects

• Digestive issues: nausea, vomiting, diarrhea, constipation, indigestion, heartburn, stomach ache (PharmEasy, MedPlusMart, 1mg).
• Urine discoloration (yellowish) — typically harmless (1mg).
• Headache and mild skin rash may occur (Medcart).

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⚠️ Less Common / Serious Risks

• Liver enzyme increase — monitor if you have pre-existing liver conditions (Medcart, 1mg, TrueMeds).
• Allergic skin reactions — though rare, can occur (Medcart, MedPlusMart).
• Asthma, glaucoma, diabetes, or blood-thinning meds may interact with glucosamine/MSM (Medcart).

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⚠️ Who Should Be Cautious

• Liver or kidney disease: may be unsafe or require close monitoring (crinovahealthcare.com).
• Pregnant or breastfeeding: insufficient safety data—consult your doctor (PlatinumRx).
• Shellfish allergy: glucosamine is often derived from shellfish—advice needed if allergic (TrueMeds).
• Other medications: possible interactions with anticoagulants, diabetes drugs, chemotherapy, etc. (TrueMeds).
• Alcohol: high intake may further stress the liver—use caution (Medcart).

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💡 How to Use

• Take with food to minimize stomach discomfort (PharmEasy).
• Typical dose is as prescribed—usually 1 tablet once or twice daily (Medcart).
• Missed dose: take when remembered, unless it’s near the next dose. Do not double dose (1mg, crinovahealthcare.com).
• Treatment duration: often recommended for several weeks or months—evaluate efficacy after a few months (1mg, PlatinumRx, PharmEasy).

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✅ Summary Table

Feature	Details
Condition treated	Osteoarthritis (knees, hips)
Main ingredients	Diacerein 50 mg, Glucosamine 446‑750 mg, MSM 250 mg
Onset of benefits	Several weeks
Common side effects	GI upset, urine color change, headache, rash
Precautions	Liver/kidney disease, allergies, pregnancy, drug interactions